Alternatively, if only one (TSH, ACTH, or prolactin) deficiency was present, the coexistence of central diabetes insipidus, neonatal symptoms of pituitary deficiency (hypoglycemia or hypogenitalism), sellar or suprasellar surgery or tumor (excluding microadenomas), clinical or radiological craniofacial midline abnormalities, or cranial radiotherapy ≥18 Gy, also led to a safe diagnosis. This evidence concerns the gene POMC and pituitary deficiency.