On the other hand, the “Guidelines for the treatment of children with GHD, idiopathic short stature, and primary insulin-like growth factor 1 deficiency” of the Pediatric Endocrine Society (PES) suggest that in patients with auxological criteria, hypothalamic-pituitary defects and deficiency of at least one additional pituitary hormone, GHD diagnosis could potentially be established without performing GHSTs (1). The gene discussed is IGF1; the disease is hyperinsulinemic hypoglycemia, familial, 4.