Additionally, it has been shown that infections of mice with different species of parasitic helminths are associated with significant increases in ILC2s, eosinophils, M2 MACs, and Th2 cytokines that result in restoration of glucose levels and improved insulin sensitivity in mouse models of obesity (3, 4, 21–24). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.