Recently, the number of studies describing a role for LCN2 in metabolic homeostasis (Yan et al., 2007; Jun et al., 2011; Guo et al., 2012, 2016; Mosialou et al., 2020) and the pathogenesis of diabetes-related complications is on the rise, indicating similar importance of LCN2 in diabetes-related neurological disorders. Here, LCN2 is linked to diabetes mellitus.