Based on the previous observations of the induction of LCN2 expression and its role in neuroinflammation in the brains of mice with diabetes or various demyelinating diseases (Nam et al., 2014; Chun et al., 2015; Al Nimer et al., 2016), Bhusal et al. (2020) have recently provided evidence for a potentially novel role of LCN2 in the progression of DPN. The gene discussed is LCN2; the disease is demyelinating disease.