Nevertheless, in the majority of the t-NGS panels reported, globin genes are not included, since globin genes are quite short and molecular diagnosis of most common Hb disorders, such as sickle cell disease (SCD) and thalassemia syndromes, is well-established through Sanger sequencing and GAP-PCR/MLPA. This evidence concerns the gene GSTM1 and Schnyder corneal dystrophy.