CFTR and cystic fibrosis: Moreover, the effects of available and recently approved drugs that correct the trafficking of variant CFTR channels, including lumacaftor (VX-809), tezacaftor (VX-661), and elexacaftor (VX-445), or potentiate their channel gating activity (ivacaftor, VX-770), on bioactive lipid metabolism and downstream inflammatory signaling of CF airway epithelia have not been fully investigated.