We have shown previously that GSH supplementation reduced the enhanced growth factor (AREG) and pro-inflammatory cytokine (IL6R) shedding in CF HBEC-ALI, by oxidative inactivation of the EGFR/ADAM17 axis in CF HBEC-ALI (Stolarczyk et al., 2016, 2018). The gene discussed is ADAM17; the disease is acute respiratory distress syndrome.