Finally, the vitamin A analog fenretinide, which has previously been shown to correct the LCC/VLCC ratio in immortalized CF cell models (Garic et al., 2017) and CFTR KO mice (Youssef et al., 2020c), partially normalized all lipid levels in KO pigs towards those observed in WT pigs. The gene discussed is CFTR; the disease is cystic fibrosis.