A study evaluating the effects of voluntary running on animals with CC induced by different tumor types found a positive regulation of both pro- and anti-inflammatory cytokines (IL-6, IL-1β, TNFα, iNOS), intense mobilization and trafficking of NK cells (natural killer) and lower incidence and reduction of tumor volume by up to 60% (Pedersen et al., 2016). This evidence concerns the gene IL1B and neoplasm.