While the role/modulation of CD39/CD73 activity in GBM still needs further elucidation in vivo experimental models/patients and the extracellular purine level measurement is difficult, especially in vivo, given the rapidity by which these compounds are metabolized (nucleotides) or transported inside cells (nucleosides), at present search for A3R/P2X7R expression level in GBM surgical specimens seems more feasible, likely opening a new prognostic/therapeutic scenario. This evidence concerns the gene NT5E and glioblastoma.