Cannabis oil with CBD:THC ratio of 20:1. The dosage ranged from 1 drop (0.05 ml) three times a day to 20 drops three times a day, for 6 months. Each drop (0.05 ml) contained 45% olive oil, 30% CBD (15 mg), and 1.5% THC (0.75 mg). The average dose was 79.5 ± 61.5 mg CBD and 4.0 ± 3.0 mg THC; patients with insomnia received an additional average dose of THC (3%) 5.0 ± 4.5 mg. This evidence concerns the gene OPN1MW and insomnia.