Among ATP receptors, the P2X7R is the subtype most convincingly associated to tumor growth (Adinolfi et al., 2012; Giuliani et al., 2014; Amoroso et al., 2016), and at the same time involved in the modulation of NTPDase1/CD39 and NT5E/CD73 expression in the TME (De Marchi et al., 2019). Here, NT5E is linked to neoplasm.