NT5E and inflammatory bowel disease: In a different animal model of IBD, i.e. post-inflammatory ileitis following 2,4,6-trinitrobenzenesulfonic acid (TNBS)-treatment, lack of adenosine increase following ATP release into the inflamed tissue is hypothesised to be at least partially due to feed-forward inhibition of muscle-bound NT5E/CD73 by excess ATP/ADP (Vieira et al., 2014; Vieira et al., 2017).