GFAP and Grade I preterm intraventricular hemorrhage: Mori et al. (2017) showed that 21 days after bilateral carotid artery occlusion in adult mice, there was an increase in immunoreactivity for GFAP in the CA1 and CA3 hippocampal regions, with augmented total levels of GFAP in the hippocampus. CBD prevented these alterations. Furthermore, in newborn rats exposed to collagenase-induced germinal matrix hemorrhage, CBD treatment reduced the number of reactive astrocytes (GFAP-positive) and caspase-3 positive-astrocytes in the perilesional area (Abrantes de Lacerda Almeida et al., 2019).