In the current study, we determinate the impact of three gene polymorphisms involved in the metabolism of antineoplastic drugs, such as the NCF4 rs1883112, CBR3 rs1056892 and ABCC1 rs3743527 polymorphisms, we also provided frequencies of this variants and identify any association with the development of ALL in children. This evidence concerns the gene NCF4 and acute lymphoblastic leukemia.