In the rs1056892 polymorphism of the CBR3 gene, a protective association was found in the heterozygous allele of the codominant model (OR = 0.3448, CI = 0.1375–0.8896 and p = 0.0274), in addition, the recessive inheritance model for the HM genotype shows a protective effect to ALL (OR = 0.52, IC = 0.9919 to 3.8638 and p = 0.05). This evidence concerns the gene CBR3 and acute lymphoblastic leukemia.