Unlike the previous results, in our study, the importance of a polymorphism that modifies the sequence of the “CBR” family gene is reflected, since it was found that for the CBR3 rs1056892 polymorphism there is a significant association of risk to ALL in presence of the HT genotype (OR = 2.7750 (IC = 1.3857–5.5651), p = 0.004), however, when analyzing the inheritance models we found that in the case of the codominant inheritance model, the heterozygous allele of the CBR3 gene constitutes a protection factor according to the obtained values (OR = 0.3448 (IC = 1.375 to 0.8896), p = 0.02). The gene discussed is CBR3; the disease is acute lymphoblastic leukemia.