These results coincide, although to a lesser extent with what was found in our work, in which other polymorphisms are related to an increased susceptibility to ALL, such as the case of NCF4 rs1883112, became evident since this factor NCF4 could influence the susceptibility of presenting ALL through this polymorphism, as it hinder the action of folic acid and promote the risk of developing ALL, possibly by making it difficult to transform the folic acid to THF, through the de-hydro folate reductase dDHFR which is dependent on NADPH oxidase. The gene discussed is NCF4; the disease is acute lymphoblastic leukemia.