Those with early nephrotoxicity on the third day tended to receive a higher total dose of polymyxin B and concomitant tigecycline treatment, and had reduced baseline albumin levels (30.5 ± 5.4 g/L vs. 33.9 ± 5.5 g/L, p = 0.01) and pre-existing kidney injury. The gene discussed is ALB; the disease is kidney injury.