The cytokine storm in COVID-19 results in IL-6 dependent alterations in the expression of vascular endothelial growth factor and E-cadherin expression on endothelial cells contributing to vascular leakage and pulmonary hypertension, and respiratory distress in COVID-19 patients (Lukan, 2020; Moore and June, 2020). The gene discussed is CDH1; the disease is COVID-19.