The results revealed that in the hippocampal CA3 region, the expression levels of inflammatory molecules including TNF-α [F(3, 55) = 40.375, p < 0.001; Figures 3A,B], COX-2 [F(3, 41) = 9.779, p < 0.001; Figures 4A,B], and iNOS [F(3, 58) = 11.68, p < 0.001; Figures 5A,B], were significantly increased in the untreated and sham 3xTg-AD group compared with the untreated WT mice. This evidence concerns the gene TNF and Alzheimer disease.