There is increasing evidence that suggest Slit2 is associated with some neuropsychiatric disorders, including MDD (Huls et al., 2020), AD (Li et al., 2015), Parkinson's disease (PD) (Lin and Isacson, 2006), TLE (Fang et al., 2010), and ASD (Perez et al., 2016; Gorker et al., 2018). This evidence concerns the gene SLIT2 and Alzheimer disease.