SLIT2 and Anxiety: In the 21-week-old mice, the duration of time spent at the center [t(18) = 2.132, p = 0.0470, Figure 2E] and the percentage of distance traveled at the center [t(18) = 3.179, p = 0.0052, Figure 2D] of the open field were lower in Slit2-Tg mice than in 21-week-old WT mice, illustrating an anxiety-like state but an increased activity level in 21-week-old Slit2-Tg mice.