TRPV1 and migraine disorder: Activation of TRPV1-expressing trigeminal afferents by stimuli implicated in migraine (e.g., capsaicin, civamide, endovanilloids) on the one hand leads to the release of CGRP and activation of CGRP receptors on blood vessels, causing vasodilation and contributing to neurogenic inflammation and, on the other hand, to the generation of action potential signaling into the trigeminal nucleus caudalis and ultimately to headache (Benemei and Dussor, 2019).