TRPV1 and irritable bowel syndrome: For instance, expression profiling of various TRPV family members in colonic biopsies from patients with ulcerative colitis (UC) shows statistically decreased TRPV1 expression in their mucosal epithelium in comparison to non-inflamed intestine samples from a control group of patients with no inflammatory bowel disease (IBD) (Rizopoulos et al., 2018).