Furthermore, capsaicin belongs to the group of dietary phytochemicals demonstrating anticancer activity (Clark and Lee, 2016), and its action in glioma and urothelial cancer cells is shown to induce TRPV1-mediated, Ca2+-dependent apoptosis (Amantini et al., 2007; Santoni et al., 2012). Here, TRPV1 is linked to central nervous system cancer.