Functional expression of TRPV1 is also demonstrated in several human carcinomas (i.e., malignancies that develop from epithelial cells) and cancer cell lines derived from them, including prostate cancer, breast cancer, thyroid carcinoma, urothelial cancer, and glioma (reviewed in Bujak et al., 2019) with cancer cells generally showing lower TRPV1 expression as compared with the normal cells from which they originate. Here, TRPV1 is linked to central nervous system cancer.