Mutations in the progranulin precursor gene (GRN; HGNC ID: 4601) causing impaired production or secretion of progranulin are a common Mendelian cause of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP; MIM 607485) (Van Deerlin et al., 2010). This evidence concerns the gene MTSS1 and frontotemporal dementia.