Taking into account the existing evidence in the literature, i.e., the nesfatin-1-mediated rescue of rotenone-induced cell apoptosis in dopaminergic cells (Tan et al., 2015) and MPTP-induced dopaminergic neuron loss in the SNpc (Shen et al., 2017), as well as the reduced nesfatin-1 blood levels in PD patients (Emir et al., 2019), we postulate that the brain peptide nesfatin-1 plays a critical role in maintaining the normal function of the nigrostriatal dopaminergic system. Here, NUCB2 is linked to Parkinson disease.