KCNC3 and fragile X syndrome: Fragile X syndrome, the leading known cause of inherited intellectual disability, results from mutations that suppress the expression of Fragile X Mental Retardation Protein (FMRP), a mRNA binding protein that controls the function and the expression level of a variety of proteins including several ion channels such as the Kv3.1, Kv3.3, Kv1.2 and KNa1.1channels (Darnell et al., 2001; Brown et al., 2010; Strumbos et al., 2010a; Zhang et al., 2012; Yang et al., 2018).