The high expression level of MMP2 was positively related to metastasis of PC and BCL-2 was a protective factor that prevented PC from apoptosis through the combination of molecules and signaling pathways, such as in PTEN loss and p53 inactivation, PI3K/AKT phosphorylation, activation of RTK/STAT3/NF-kB, Ras/Raf1/MEK/ERK, microRNAs (miR-24, miR-31, miR-34, miR-195, miR-204, miR-205 and lncRNA MEG3), autophagy proteins (Beclin1 and AMBRA1) and other potent molecules (FKBP38/NR4A1/GAL3) 60, 61. This evidence concerns the gene RAF1 and pachyonychia congenita.