YAP1 and pachyonychia congenita: The YAP1 and AMPK signaling pathway activated in PC and had strong association with pathogenesis 81, 82, which furnished fresh thought to Jinet al. Fortunately, they had explored that the ratio of p/t-AMPK and level of YAP1 was declined when sh-circZNF609 involved and the result was reversed with the effect of transfection of miR-186-5p 46.