There are seven imperative signaling cascades prompting the development and progression of PC: Androgen receptor (AR) mediated signaling pathway; NF-kB signaling pathway; Growth factor signaling pathway; Phosphoinositide-3-kinase/AKT signaling pathway; Janus Kinase/signaling transducers and activators of transcription (JAK/STAT) signaling; MAPK pathway; Wnt/β-catenin signaling pathway. This evidence concerns the gene NFKB1 and pachyonychia congenita.