A study of DHA in melanoma showed that DHA induced the proliferation of IFN-γ+CD8+ T cells in tumor microenvironment and mouse spleens, while the number of CD4+CD25+Foxp3+ T cells and IL-10+CD4+CD25+ T cells returned to normal, thus enhancing the anti-tumor immunity of mice 60. Here, CD4 is linked to neoplasm.