For instance, Fbxw7 regulates YAP protein stability by targeting YAP for ubiquitination and proteasomal degradation in hepatocellular carcinoma 44; SHARPIN and RNF187 promote YAP degradation via inducing YAP K48-dependent poly-ubiquitination 45, 46. The gene discussed is RNF187; the disease is hepatocellular carcinoma.