TP53 and cancer: The Asian Cancer Research Group (ACRG) classifies GC subtypes as high microsatellite instable, microsatellite stable/epithelial-mesenchymal transition, microsatellite stable/epithelial/TP53 intact, and microsatellite stable/epithelial/TP53 loss; these subtypes encompass GC heterogeneity and provide useful clinical information [28].