Akkermansia are typically linked to health beneficial and anti-inflammatory effects [33], such as improving glucose homeostasis in diet-induced obesity [34], and slowing progression of dextran sulfate sodium-induced colitis [35], although the mucin degradation properties of the members of this genus may also exacerbate certain types of infection [36]. The gene discussed is MUC5AC; the disease is obesity due to melanocortin 4 receptor deficiency.