Previous research has been reported that miR-130b-3p present in exosomes contributes to CXCL12/CXCR4-induced colorectal cancer metastasis into liver [22] and downregulate PIEZO2, thereby activating the Hedgehog signaling pathway and leading to worsening breast cancer prognosis [23]. This evidence concerns the gene PIEZO2 and colorectal cancer.