Through analysis of the genome-wide mRNAs, microRNAs (miRNAs) and methylation profiles from LUAD project in The Cancer Genomics Atlas (TCGA) and the web-based bio-tool Lung Cancer Explorer (LCE) [15], we showed evidence for the use of AURKB as a prognosis biomarker in LUAD patients, and demonstrated potential genomic and epigenomic mechanisms associated with AURKB expression, explaining how AURKB accelerated the lung adenocarcinoma progression and limited patients’ survival. The gene discussed is AURKB; the disease is lung cancer.