In the dyslipidemia group, rs2222896A-rs2548861T haplotype carriers had lower TC and ApoB levels, but higher HDL-C and ApoA levels and ApoA1/ApoB ratio than those without corresponding haplotype (P < 0.001), rs2222896A-rs2548861G haplotype carriers had lower LDL-C and higher ApoA1 and TG levels than those without corresponding haplotype (P ≤ 0.004), and rs2222896G-rs2548861T haplotype carriers had lower ApoA1 and HDL-C levels and ApoA1/ApoB ratio than those without corresponding haplotype (P < 0.001). This evidence concerns the gene APOA1 and metabolic syndrome.