In the dyslipidemia group, the rs2222896A-rs2548861T haplotype was associated with decreased serum TC and ApoB levels and increased serum HDL-C and ApoA1 levels and ApoA1/ApoB ratio (P < 0.001), the rs2222896A-rs2548861G haplotype was associated with decreased serum LDL-C levels and increased serum ApoA1 (P ≤ 0.006) and TG levels (P < 0.001), and the rs2222896G-rs2548861T haplotype was associated with decreased serum ApoA1 and HDL-C levels and ApoA1/ApoB ratio (P < 0.001). The gene discussed is APOA1; the disease is metabolic syndrome.