Among these genes, CYP2E1, SLN, BMP2, MYH7, RNF185 and PDIA3 were protective factors for glioma survival, with hazard ratios (HRs) <1, and BRCA1, CISD2, LRRK2, HSPB1, DNM1L, SHISA5, RCN1, SPP1, RPN2 and ATP2A2 were risk factors with HRs > 1. Here, SPP1 is linked to central nervous system cancer.