Expression levels of risk factors BRCA1, DNM1L, RCN1, HSPB1, RPN2, LRRK2 and SPP1 in high‐grade gliomas were greater than those in lower‐grade gliomas, while the protein expression levels of protective factor PDIA3 were exactly the opposite (Figure S2). This evidence concerns the gene PDIA3 and central nervous system cancer.