To provide further evidence, the colon adenocarcinoma (COAD) samples from TCGA database was utilized, and a significant correlation was observed between CYGB and YAP1 (r = 0.34, P < 0.0001, Figure 6E) and between CYGB and ACSL4 (r = 0.32, P < 0.0001, Figure 6F), which was also detected based on the data from Cancer Cell Line Encyclopedia (CCLE) databases (Figure S3A and B). The gene discussed is ACSL4; the disease is colon adenocarcinoma.