BRCA1 and breast cancer: Previous studies indicate that acceptability of PND varies strongly, with a majority of breast cancer gene (BRCA1/2) mutation carriers finding it a too drastic measure to prevent HBOC, but couples with Huntington Disease overall finding PND acceptable, even if they had to terminate the pregnancy (Derks-Smeets et al. 2014; Dommering et al. 2017).