For examples, FTO has been demonstrated to associate with obesity and inhibit mitochondrial functions in adipocyte precursors via ARID5B-mediated repression of IRX3 (iroquois-related homeobox 3) and IRX5, and silencing FTO resulted in high m6A methylation on ATG5 and ATG7 mRNAs recognized by YTHDF2, leading to mRNA degradation and reduced autophagy and adipogenesis146,147. This evidence concerns the gene FTO and Obesity.