FTO and obesity due to melanocortin 4 receptor deficiency: For examples, FTO has been demonstrated to associate with obesity and inhibit mitochondrial functions in adipocyte precursors via ARID5B-mediated repression of IRX3 (iroquois-related homeobox 3) and IRX5, and silencing FTO resulted in high m6A methylation on ATG5 and ATG7 mRNAs recognized by YTHDF2, leading to mRNA degradation and reduced autophagy and adipogenesis146,147.