Vu et al. provided evidence showing that METTL3 was highly expressed in AML, which elevates the installed m6A level in BCL2 and PTEN transcripts with, increased translation efficiency, leading to activation of AKT signaling to modulate the cell differentiation and self-renewal of acute myeloid leukemia cells172. Here, METTL3 is linked to acute myeloid leukemia.