Importantly, m6A sequencing in human type 2 diabetes islets revealed multiple hypomethylated transcripts involved in insulin secretion, cell-cycle progression and the Insulin/IGF1 pathway, and METTL14 knockout in mouse β-cell resulted in reduced m6A levels, leading to similar islet phenotype in human T2D and mortality223. Here, IGF1 is linked to type 2 diabetes mellitus.