One bioinformatics study using The Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) datasets showed that METTL3, METTL14, WTAP, RBM15, RBM15B, YTHDC2, YTHDF1, YTHDF2, YTHDF3, hnRNPA2B1, and hnRNPC are differentially expressed in gliomas accompanied with increased WHO grade, indicating that m6A RNA methylation regulators play important role in glioma malignancy183. Here, METTL3 is linked to central nervous system cancer.