METTL3 and central nervous system cancer: For example, METTL3 or METTL14 knockdown robustly promotes glioma stem cell (GSC) self-renewal and tumorigenesis through increasing expression of stemness marker genes (e.g., ADAM19), while overexpression of METTL3 or inhibition of FTO inhibits GSC self-renewal and grafted tumor formation in vivo184.