Consistently, the overall m6A level was elevated in the cortex and the hippocampus of APP/PS1 (Alzheimer’s disease) mice compared to C57BL/6 control mice, and FTO was found to interact with APOE, which is associated with Alzheimer’s disease risk in a prospective cohort study216,217. This evidence concerns the gene FTO and early-onset autosomal dominant Alzheimer disease.