TP53 and hepatocellular carcinoma: Accordingly, miRNA-1246 targets p53, phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT), mitogen-activated protein kinase (MAPK), and mammalian target of rapamycin (mTOR) signalling pathways, leading to apoptosis in paclitaxel-treated HCC cells [23].