The only distinguishing features between recent and remote infection were higher M.tb-specific T cell activation and lower proportions of M.tb lysate-specific KLRG-1+ IFN-γ+TNF+IL-2- TE cells in recently compared to remotely infected individuals, while CFP-10/ESAT-6-specific T cell functional and memory profiles were very similar. Here, KLRG1 is linked to infection.