We investigated whether CSF Nfs reflected the progression rate in ALS patients; we found a significant correlation between both p‐NfH (r = 0.443, P = .0125) and NfL levels (r = 0.4574, P = .0097) and progression rate in ALS cohort (Figure 4A, B). This evidence concerns the gene NEFL and amyotrophic lateral sclerosis.