TMPRSS2 and prostate adenocarcinoma: To further understand the mechanism of how methylation modification affects TMPRSS2 expression, methylation analysis of TMPRSS2 promoter in PRAD revealed that the methylation of the TMPRSS2 promoter in PRAD is slightly increased compared to that in normal tissue, implying that hypomethylation of TMPRSS2 promoter may not be the mechanism for TMPRSS2 overexpression in PRAD tumour tissues and PRAD's pathogenesis.