In addition, treating 7-month-old APP/PS1 mice with antidiabetics liraglutide decreased amyloid plaque load and the level of soluble amyloid oligomers in the cortex, along with prevention of the synapse loss and deterioration of synaptic plasticity in the hippocampus, commonly observed in this mouse model of AD [103]. Here, PSEN1 is linked to Alzheimer disease.