Thus, in line with non-IBD patients, IBD patients with severe COVID-19 showed a higher age and multiple comorbidities.54 Accordingly, data from the Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD), a large, international registry, identified increasing age, ≥2 comorbidities as well as corticosteroids, thiopurins as well as combination of thiopurins and TNF-blockers to be associated with severe COVID-19.57 The gene discussed is TNF; the disease is COVID-19.