CXCL8 and injury: The CXCL1, CXCL2 and IL-8/CXCL8 chemokines mediate neutrophil recruitment and activation via CXCR1/CXCR224–26, and reparixin has been reported to inhibit neutrophil-mediated inflammatory responses in mouse models of acute lung injury and lung transplantation23,27–29.