The antiproliferative activity of synthesized phytol derivatives was evaluated against selected cancer cell lines (leukemia, lung and colon carcinoma and its doxorubicin resistant subline) whereas their molecular mechanism of action including of cell cycle, cell death evaluation and their influence on the activity of caspase 3/7 were studied towards human biphenotypic B myelomonocytic leukemia cell line MV4-11. The gene discussed is CASP3; the disease is cancer.