CFTR and cystic fibrosis: Two asymptomatic seropositive individuals had conditions that theoretically could impact immune activation and/or response to COVID-1922, one individual with Cystic Fibrosis (CFTR G551D mutation) and one individual with Nuclear factor-kappa B Essential Modulator (NEMO) deficiency (Incontinentia pigmenti, IKBKG exon4_10del mutation) (Table 1).