In general, APO treatment did not affect the locomotor activity or anxiety in HMF-exposed when returning to GMF (Supplementary Fig. 12a–d), However, APO treatment was able to prevent the restoring effect of return to GMF on the exploratory time towards objects in both NOL and NOR tests (Supplementary Fig. 12e, f) in HMF-exposed mice. This evidence concerns the gene AOPEP and Anxiety.