The occurrence of Mo/MΦ expressing an inflammatory Il1b, along with Il1rn and Il18b (coding for the inhibitors of pro-inflammatory cytokines) and Cd274 is interesting for its clinical relevance, suggesting that pro-invasive and immunoregulatory functions are split between MG and MΦ in the glioma microenvironment, respectively. This evidence concerns the gene CD274 and central nervous system cancer.