The convergence of the Der1 mutation with a subset of putative common genetic risk factors for schizophrenia and depressive disorders, and the convergence of this subset of genes upon synapses and synaptic plasticity6,54 implies that, of all the Der1 cortex pathway predictions, dysregulated neurotransmission and synaptic plasticity are among the most critical factors in the psychiatric symptoms of t(1:11) translocation carriers. This evidence concerns the gene DERL1 and depressive disorder.