Considering the limited tumor nodules in c-Myc/TGFβ1 HCC model, one plausible explanation is that a small percentage of c-Myc injected hepatocytes were able to induce the expression of these anti-apoptotic genes, thus escaping TGFβ1 induced apoptosis. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.