Consistently, in human HCC samples, we discovered that TGFβ related downstream EMT targets such as CREBBP43, EP30044, APC45, SKIL46, and MAP2K1 (MEK1)47 are not overexpressed in c-MYC amplified tumor samples based on TCGA LIHC data analysis (Supplementary Fig. 12). Here, MAP2K1 is linked to hepatocellular carcinoma.