SLC39A8 and schizophrenia: Given the evidence for glutamate hypofunction as a major pathology in schizophrenia and that glutamate receptors are inhibited by excess zinc at axon terminals upon neuronal activity, we addressed the role of zinc import by ZIP8 in neurotransmission by using short hairpin RNA (shRNA) lentivirus targeting Zip8 or Luciferase in cultured rat hippocampal neurons.