We used multiple open-source large datasets to identify the potential target genes regulated by CDKN2B-AS1, and also proved in vivo and in vitro that CDKN2B-AS1 affects KIRC tumor growth and metastasis, at least partly through NUF2, which can also serve as an oncogene to promot tumor progression32,33. This evidence concerns the gene NUF2 and neoplasm.