TNFRSF1A and Parkinson disease: Human genetics provides valuable guidance for therapeutic programs because the chances of successful drug development are substantially improved when genetic evidence links a drug's target to an indication for therapeutic use.39 Hence, our findings should be considered as part of discourse on the repurposing potential of TNF inhibitors for PD prevention and treatment, particularly if selective inhibitors of TNF-TNFR1 signaling become available.