Correspondingly, lack of both Fr I and II macrophages rendered CX3CR1gfp/gfp mice to be very susceptible toward systemic candidiasis (Fig S2C), with an exceedingly high renal fungal burden as early as day 1 p.i. when compared with infected WT and CD169-DTR mice (Fig S2D). The gene discussed is SIGLEC1; the disease is candidiasis.