SIGLEC1 and infection: Because kidneys were the only organs where C. albicans accumulated during the infection (Fig 2A), we next performed histopathologic examination of periodic acid–Schiff (PAS) (Fig 2C)– and H&E (Figs 3A and S3)–stained sections obtained from infected WT and CD169-DTR kidneys at day 3, 6, and 10 p.i. At day 3, signs of renal damage and hemorrhages were observed in CD169-DTR kidneys (Fig S3A).