In particular, transcripts levels of perilipin 2 – which is essential for the structural integrity of LDs and has been shown to be positively correlated with hepatic steatosis (Alves-Bezerra and Cohen, 2018; McIntosh et al., 2012; Motomura et al., 2006; Najt et al., 2016) – were substantially decreased. The gene discussed is PLIN2; the disease is fatty liver disease.