Indeed, the hypometabolic pattern of the “limbic-predominant” subtype identified in the present study shows a striking resemblance with a recently described FDG-PET pattern of pathologically confirmed patients with AD dementia with comorbid TDP-43 pathology and hippocampal sclerosis (HS) [48] (specifically, Fig. 3, page 1209 in that study). Here, TARDBP is linked to histiocytic sarcoma.