FH and renal cell carcinoma: FH-RCC has been described in the pathology literature as typically having FH-deficiency or 2-succino-cysteine (2SC) positive immunoreactivity on immunohistochemical (IHC) analysis, and can be distinguished histologically by papillary architecture with abundant eosinophilic cytoplasm, large nuclei, and very prominent nucleoli with perinucleolar clearing [7–9].